whipple

Overview & Epidemiology Whipple disease (WD) is a rare, systemic granulomatous infection caused by Tropheryma whipplei, first described by George Whipple in 1907. With fewer than 1,000 cases reported globally, it remains one of the rarest human infections—incidence estimated at <1 per million person-years (Roux et al., Clin Microbiol Rev, 2023). It predominantly affects middle-aged…