I. Introduction & Pathobiology Acute promyelocytic leukemia (APL; AML-M3, FAB classification) is a distinct, life-threatening subtype of acute myeloid leukemia (AML) accounting for 10–15% of AML cases in adults and…

Epidemiology and Pathobiology: Clinical Relevance Acute lymphoblastic leukemia (ALL) accounts for ~75% of acute leukemias in children but only ~20% in adults, with a median age at diagnosis of ~65…

Epidemiology & Pathogenesis CMML is a clonal hematopoietic stem cell disorder classified under the myelodysplastic/myeloproliferative neoplasm (MDS/MPN) overlap syndromes. It exhibits features of both dysplasia and proliferation, with characteristic persistent…