Comprehensive Clinical Update on Duchenne Muscular Dystrophy: Pathophysiology, Diagnosis, Management, and Emerging Therapeutics
Epidemiology & Inheritance Pattern – Beyond Basic Genetics Duchenne Muscular Dystrophy (DMD) is a severe, progressive, X-linked recessive myopathy caused by mutations in the DMD gene (Xp21.2), encoding the 427-kDa dystrophin protein. Incidence: ~1:3,500–5,000 live male births (Tan et al., Neurology, 2022; Bushby et al., Lancet Neurol, 2023). Molecular Pathogenesis – From Gene to Functional…
