Tag: stiff person syndrome

Stiff-Person Syndrome (SPS) is a rare, progressive autoimmune disorder characterized by progressive muscle stiffness (rigidity), painful muscle spasms, and heightened sensitivity to stimuli. First described in 1956, SPS is now recognized as a spectrum of disorders, including variants such as stiff-limb syndrome (SLS) and stiff-person syndrome with brainstem involvement. The condition typically develops gradually over…