Russell-Silver Syndrome: Clinical Overview, Diagnostic Approach, and Evidence-Based Management Strategies
Updated with Current Genetic Insights and Management Recommendations (2024) Epidemiology and Clinical Definition Russell–Silver syndrome (RSS; OMIM #180860, #601803) is a rare, clinically and genetically heterogeneous congenital growth disorder characterized by severe prenatal and postnatal growth retardation, relative macrocephaly at birth, characteristic facial features, body asymmetry, and feeding difficulties. Estimated incidence ranges from 1:30,000 to…
