Lamivudine

1. Introduction Lamivudine (3′-hydroxy-3′-thiacidopyrimidine, 3TC) is a nucleoside reverse transcriptase inhibitor (NRTI) and one of the most widely used antiviral agents in the management of HIV infection and chronic hepatitis B virus (HBV) disease. Its broad-spectrum activity against both HIV-1 and HIV-2, as well as HBV, makes it an essential component of combination antiretroviral therapy…