Clinical Overview of Prader-Willi and Angelman Syndromes
Introduction: Genomic Imprinting on Chromosome 15q11-q13 Prader-Willi Syndrome (PWS) and Angelman Syndrome (AS) are classic examples of genomic imprinting, where the expression of a gene depends on its parental origin. Both disorders involve the 15q11-q13 region, but they result from the loss of different genes due to epigenetic silencing. Correction Note: The original text mentions…
