Comprehensive Clinical Review of Brugada Syndrome: Pathophysiology, Diagnosis, Risk Stratification, and Evidence-Based Management
1. Definition and Epidemiology Brugada syndrome (BrS) is a rare, inherited primary electrical disorder characterized by a distinctive electrocardiographic (ECG) pattern—classically coved-type ST-segment elevation in right precordial leads (V1–V3)—and an increased risk of sudden cardiac death (SCD) due to polymorphic ventricular tachycardia (VT) or ventricular fibrillation (VF), often during rest or sleep. The underlying structural…
