What is Nabumetone?
Nabumetone is an anti-inflammatory medication that is not a steroid (NSAID). Nabumetone works by decreasing the amount of hormones in the body that cause inflammation and pain.
Nabumetone uses
Nabumetone is used to treat arthritis-related pain, swelling, and joint stiffness. This drug is referred to as a nonsteroidal anti-inflammatory drug (NSAID) (NSAID). If you are treating a chronic condition such as arthritis, speak with your doctor about non-drug treatment options and/or the use of alternative medications to manage your pain.
Mechanism of action
Nabumetone is a prodrug that is converted to the active moiety 6-methoxy-2-naphthyl acetic acid via hepatic catalysis (6MNA). 6MNA inhibits the activity of cyclo-oxygenase I and II, resulting in a decrease in the production of precursors to prostaglandins and thromboxanes.
Nabumetone dosage
Tablet – 500mg ,750mg
Osteoarthritis:
1000 mg PO once daily initially; 1000-2000 mg PO daily in a single daily dose or divided every 12 hours thereafter; not to exceed 2000 mg/day.
Arthritis Rheumatoid:
1000 mg PO once daily initially; 1000-2000 mg PO daily in a single daily dose or divided every 12 hours thereafter; not to exceed 2000 mg/day.
Modifications to the Dosage:
750 mg/day initially; not to exceed 1500 mg/day in moderate renal impairment (CrCl: 30-49 mL/min).
Severe renal impairment (CrCl: <30 mL/min): 500 mg/day initially; not to exceed 1000 mg/day
Administration
Nabumetone comes as a tablet to take by mouth. It is usually taken once or twice a day with or without food.
Side effects of Nabumetone
Common side effects of Nabumetone include:
- Diarrhea
- Indigestion/heartburn
- Abdominal pain
- Constipation
- Dizziness
- Swelling (edema) (edema)
- Gas (flatulence) (flatulence)
- Headache
- Nausea
- Positive stool guaiac
- Itching of the skin
- Rash
- Fatigue
- Pain or discomfort in the stomach or abdomen
- Increased perspiration
- Insomnia
- Nervousness
- Drowsiness
- Swelling and sores inside the mouth
- Vomiting
- Bloating
- Perplexed vision
Drug-drug interactions
Significant interactions
Typically, these drugs are not taken concurrently. For additional information, consult your healthcare provider (e.g., doctor or pharmacist).
- Nephrotoxic agents selected/cidofovir
- Nephrotoxic agents/bacitracin selected
- NSAIDS; aspirin/ketorolac (> 81 mg) (injectable)
- NSAIDS; aspirin/ketorolac (> 81 mg) (non-injection)
Interactions that are serious
These drugs may interact, resulting in extremely serious side effects. For additional information, consult your healthcare provider (e.g., doctor or pharmacist).
- Nephrotoxic agents selected/foscarnet
- Anti-inflammatory drugs/inotersen which are not steroidal
- Growth agents hormone/macimorelin
- Abixaban/nsaids; betrixaban; edoxaban; rivaroxaban
- NSAID/dabigatran
- NSAIDS/mifamurtide
- Bowel cleaner with nsaids/sodium phosphate
- Nephrotoxic agents/colistimethates selected
- NSAID/inhibitors of selected platelet aggregation
- NSAID with a long half-life; diflunisal/pemetrexed
- Nonsteroid anticoagulants/selected anticoagulants (vit k antagonists)
- Cyclosporine/nsaids; everolimus; sirolimus; tacrolimus
- Pralatrexate; nsaids/methotrexate
Warnings/ instructions for use
Inform your doctor or pharmacist before using nabumetone if you are allergic to it, aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen, naproxen, or celecoxib), or if you have any other allergies. This product may contain inactive chemicals that may cause allergic reactions or other adverse reactions.
Storage
Keep it at room temperature (between 20 and 25°C). Keep it in an airtight container and out of reach of youngsters.
Contraindications
This medication is contraindicated in the following conditions. Consult your physician if you suffer from any of the following conditions:
Conditions:
- Mastocytosis systemic
- Heightened risk of bleeding as a result of a clotting condition
- A higher risk of bleeding
- Alcoholism
- Hypertension
- A cardiac arrest
- Heart failure is chronic
- A hemorrhagic stroke is when there is abnormal bleeding in the brain, resulting in damage to brain tissue.
- A clump of blood
- An ulcer caused by excessive stomach acid
- Gastroenteritis or intestinal ulcer
- Difficulties with the liver
- Stomach or intestines bleeding
- Transplantation of the kidney
Pregnancy or lactation
Inform your physician if you are pregnant, planning to become pregnant, or nursing. If consumed at 20 weeks or later in pregnancy, naproxen may harm the fetus and cause delivery complications. Take nabumetone only if your doctor directs you to do so during or after 20 weeks of pregnancy. Consult your doctor if you become pregnant while taking nabumetone.
