What is Xiaflex?
Xiaflex (collagenase clostridium histolyticum) is manufactured from a combination of proteins generated from a certain bacteria.
Xiaflex uses
Xiaflex is licensed by the U.S. Food and Drug Administration (FDA) for treatment of adults with Dupuytren’s contracture and for adult men with Peyronie’s illnesses with a palpable plaque and curvature deformity. It does not have any off-label usage.
Mechanism of action
Xiaflex includes pure collagenase clostridium histolyticum. When injected directly into a Dupuytren’s cord, it enzymatically destroys collagen. As a result of collagen disruption, contracture may be minimized and range of motion may be improved.
Dosage
Xiaflex, given as a lyophilized powder, must be reconstituted with the specified diluent before to use. The dose of Xiaflex is 0.58 mg per injection into a palpable cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint. Each vial of Xiaflex and sterile diluent should only be used for a single injection. If two joints on the same hand are to be treated during a therapy visit, separate vials and syringes should be used for each reconstitution and injection.
Administration
XIAFLEX should be administered by a healthcare provider experienced in injection operations of the hand and in the treatment of individuals with Dupuytren’s contracture.
Xiaflex side effects
XIAFLEX can produce serious side effects, including:
Penile fracture (corporal rupture) or other major injuries to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After therapy with XIAFLEX, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to correct the affected area. Damage to your penis might not get better following a corporal rupture. After treatment with XIAFLEX, blood vessels in your penis may also burst, causing blood to collect under the skin (hematoma) (hematoma). This could require a treatment to drain the blood from under the skin. If a hematoma occurs, skin and soft tissue necrosis (death of skin cells) may develop in that location, which could require surgery.
Xiaflex drug interaction
Some drugs can impact how collagenase, Clostridium histolyticum functions. Tell your doctor if you are on blood thinners (including high-dose aspirin or warfarin) (including high-dose aspirin or warfarin).
Precautions/ safety information
Xiaflex should not be taken by anyone who has had an allergic reaction to any collagenase product. It should also not be taken by anyone who is allergic to any of the following substances that are present in the medication:
- Hydrochloric acid
- Sucrose
- Tromethamine
- Calcium chloride dihydrate
- Sodium chloride
- Patients whose Peyronie’s disease affects the urethra should not use Xiaflex.
Storage
Store in refrigerator (36°F to 46°F; 2°C to 8°C). Do not freeze. Ensure both vials are upright prior to refrigerating.
Contraindications
Xiaflex is contraindicated in patients who:
- Have a history of bleeding difficulties.
- Use anti-coagulation medication within the week previous to injection (low dose aspirin is okay) (low dose aspirin is acceptable).
- Have had past treatment with Xiaflex for another ailment.
Pregnancy or lactation
Tell your doctor if you are pregnant or plan to become pregnant while treatment with Xiaflex. Xiaflex is not predicted to damage a fetus. It is uncertain if Xiaflex goes into breast milk or if it could affect a nursing baby. Consult your doctor before breastfeeding.
