Medullary Thyroid Carcinoma (MTC): A Comprehensive Clinical Overview for Physicians
Epidemiology & Pathogenesis Medullary thyroid carcinoma (MTC) accounts for 3–5% of all thyroid malignancies in the United States, with an annual incidence of ~0.5 cases per 100,000 persons. It arises from the parafollicular C cells (neural crest-derived neuroendocrine cells) responsible for calcitonin production. MTC is broadly classified into: Clinical Presentation: Red Flags & Nuances While…