Toxic Epidermal Necrolysis (TEN): A Clinically Focused Review with Contemporary Evidence-Based Management Guidance
Definition & EpidemiologyToxic epidermal necrolysis (TEN) is a rare, life-threatening immune-mediated adverse drug reaction characterized by widespread apoptosis of keratinocytes leading to acute skin and mucosal detachment, resembling severe burn injury. It represents the most severe end of the SJS/TEN spectrum, defined by >30% body surface area (BSA) epidermal detachment (per consensus criteria from the…
