Tag: MERRF
MERRF Syndrome (Myoclonic Epilepsy with Ragged-Red Fibers): A Comprehensive Update Based on Current Evidence
Overview Myoclonic Epilepsy with Ragged-Red Fibers (MERRF) is a rare, progressive, multisystem mitochondrial disorder primarily affecting the central and peripheral nervous systems and skeletal muscle. First described by Davies et al. in 1975, MERRF is classified among the mitochondrial encephalomyopathies and is characterized by the histopathological hallmark—ragged-red fibers (RRFs) visible on Gomori trichrome–stained skeletal muscle…
