Irinotecan: Clinical Overview for Pharmacists
1. Introduction Irinotecan is a topoisomerase I inhibitor widely used in the management of various gastrointestinal malignancies. It is a prodrug metabolized to its active form, SN-38, which exerts cytotoxic effects primarily during the S and G2 phases of the cell cycle by stabilizing DNA-topoisomerase I cleavable complexes, leading to DNA strand breaks and apoptosis….
