Type 1 Diabetes Mellitus: A Clinically Oriented Review with Emphasis on Contemporary Pathophysiology, Staging, Diagnosis, and Evolving Therapeutic Paradigms

I. Definition & Epidemiology: Beyond “Juvenile-Onset” Diabetes Type 1 diabetes mellitus (T1D) is an immune-mediated disorder characterized by progressive, T cell–mediated destruction of pancreatic β-cells leading to absolute or near-absolute…

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