Olmsted Syndrome: Comprehensive Clinical Overview for Healthcare Professionals with Current Evidence-Based Insights
Definition & EpidemiologyOlmsted syndrome (OS; OMIM #164900) is an extremely rare, non-neoplastic congenital disorder characterized by progressive, symmetrical, mutilating palmoplantar keratoderma (PPK) with periorificial hyperkeratotic lesions. First described in 1928 by Olmsted et al., fewer than 100 cases have been reported worldwide to date—predominantly from consanguineous families or sporadic occurrences—indicating extreme rarity (prevalence <1:1,000,000). While…
