Tag: huntington

A progressive, inherited neurodegenerative disorder Huntington’s disease (HD) is an autosomal dominant, inherited neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. It results from a pathogenic CAG trinucleotide repeat expansion in the HTT gene on chromosome 4, which encodes the huntingtin protein. The disorder is fully penetrant with ≥40 CAG repeats; reduced…