Ehlers-Danlos Syndrome: Clinical Overview, Diagnostic Evaluation, and Evidence-Based Management Strategies for Clinicians
I. Pathophysiology & Clinical Spectrum Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited connective tissue disorders caused by defects in collagen synthesis, processing, or structure—most commonly COL1A1, COL1A2, COL3A1, COL5A1, COL6A1–3, and genes involved in collagen modification (FKBP14, SERPINF1), extracellular matrix organization (ADAMTS2, ZNF469), or vascular integrity (ACTA2, TGFB2/3). The 2017 classification recognizes 13…
