Comprehensive Clinical Overview of Addison’s Disease: Pathophysiology, Diagnosis, Management, and Prognosis – Based on Current Evidence
Prepared for the practicing clinician 1. Definition and Epidemiology Addison’s disease—more accurately termed chronic primary adrenal insufficiency (AI)—is a life-threatening endocrine disorder characterized by the near-total loss of functional adrenal cortical tissue, resulting in deficient production of cortisol, aldosterone, and often DHEA. While historically associated with tubercular destruction, autoimmune etiology now dominates in industrialized nations….
